Scientists have found the optimal time to take vitamin D3

The time of day may affect the ability of vitamin D3 to mitigate the negative effects of prolonged stress. Researchers found that its use in the evening has a more pronounced positive effect than in the morning. The results are presented in the journal Food & Function.

During the experiment, laboratory mice were subjected to chronic stress for a month. At the same time, the animals were given vitamin D3 daily at different times of the day. The researchers tracked changes in their behavior, brain function, sleep quality and the functioning of their internal biological clock.

The results showed that the vitamin helped to alleviate stress-induced disorders regardless of the time of administration. However, in mice that received it in the evening, the signs of anxious and depressive behaviors were noticeably reduced. Also, experts recorded an improvement in the state of the hippocampus - the brain structure responsible for memory formation and learning.

Additional studies have found that evening vitamin D3 supplementation helped to normalize sleep, restore serotonin levels and reduce inflammation. In addition, the animals improved the regulation of the daily activity of certain liver genes. The authors suggest that the action of the vitamin is associated with the body’s circadian rhythms, but further research is needed to confirm a similar effect in humans.

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